Carefully chosen ingredients. Thoughtfully designed formulas. Explore the human research behind Neuropic Pro and Neuropic Spark, and why each ingredient has a place in the blend.
Good ingredients start with good questions. What has been studied in people? What did researchers find? We prioritise randomised, double-blind, placebo-controlled trials where available. We also draw on established nutrient science. Below, you’ll find the useful takeaways, with the original sources there whenever you want to explore further.
The adult formula
The science behind Neuropic Pro
From focused mornings to mentally demanding afternoons, Pro brings together L-theanine, Lion’s Mane, Rhodiola and Panax ginseng, alongside guarana and essential B vitamins.
01 / L-theanine + Guarana
Focus that keeps up with your day
L-theanine and guarana sit at the heart of Pro’s focus blend. Human research has explored L-theanine paired with caffeine, as well as guarana itself, for attention and performance during demanding tasks.
What the research found
More accurate task-switching with an L-theanine and caffeine combination in a controlled adult trial.
Greater alertness and less reported tiredness in that same trial.
Faster responses on cognitive tasks in a review of eight guarana studies, although accuracy was not improved.
In Neuropic Pro: 200 mg L-theanine + 682 mg guarana extract per 2 gummies.The guarana provides 150 mg natural caffeine.
Read the studies
L-theanine combination and attention · 2010 ↗Double-blind, placebo-controlled trial; 44 young adults. A combination of 97 mg L-theanine and 40 mg caffeine improved task-switching accuracy and alertness, and reduced reported tiredness.
Guarana and cognitive response time · 2023 ↗A meta-analysis of eight placebo-controlled studies involving 328 participants found a small improvement in response speed with guarana. Studied doses ranged from 37.5–500 mg; seven studies were double-blind and one was single-blind.
02 / Lion’s Mane + Panax ginseng
A closer look at memory
Lion’s Mane and Panax ginseng have attracted interest for their effects on memory and cognition. Trials in older adults with mild cognitive impairment offer a useful look at why these botanicals are studied.
What the research found
Higher cognitive assessment scores with Lion’s Mane after 8, 12 and 16 weeks in a small placebo-controlled trial.
Better immediate visual recall with Panax ginseng in a six-month trial.
Better delayed visual recall in that same ginseng trial, including recall after 20 minutes.
In Neuropic Pro: Lion’s Mane equivalent to 1,500 mg + Panax ginseng equivalent to 1,000 mg per 2 gummies.
Read the studies
Lion’s Mane and cognitive function · 2009 ↗Double-blind, placebo-controlled trial; 30 adults aged 50–80 with mild cognitive impairment. Participants took 3 g of tablets containing 96% Lion’s Mane dry powder daily for 16 weeks. Cognitive assessment scores were higher than placebo at weeks 8, 12 and 16.
Panax ginseng and visual memory · 2019 ↗Randomised, double-blind, placebo-controlled trial; 90 adults with mild cognitive impairment. Taking 3 g of Panax ginseng powder daily for six months improved immediate and delayed visual recall on specific memory tests.
Pro’s Lion’s Mane and ginseng amounts are raw-ingredient equivalents from 10:1 extracts. These trials used powdered preparations.
03 / Choline
A building block for brain signalling
Choline has a different role from the botanicals in Pro. It is an essential nutrient the body uses to make both chemical messengers and structural components of cells.
Why choline earns its place
Brain signalling: choline is needed to make acetylcholine, a messenger involved in memory, mood and nervous-system function.
Cell structure: the body uses choline to make phospholipids, important components of cell membranes.
Per 2 Neuropic Pro gummies: 33 mg choline.
Read about choline’s role
Choline: essential nutrition and brain function ↗The NIH Office of Dietary Supplements explains how the body uses choline to make acetylcholine, a chemical messenger involved in memory, mood and nervous-system function. Choline is also needed to make important components of cell membranes.
04 / Rhodiola rosea + Black maca
When the day asks a little more
Rhodiola has been studied during periods of stress-related fatigue, while maca research has explored mood and perceived energy. Together, they bring two distinct areas of botanical research into the Pro formula.
What the research found
Less stress-related fatigue with a standardised Rhodiola extract in a 28-day adult trial.
Improvements in selected attention measures in the same Rhodiola trial.
Reported improvements in mood and perceived energy in a 12-week study of maca extracts, with results varying by variety and altitude.
In Neuropic Pro: Rhodiola equivalent to 1,000 mg + black maca equivalent to 15,000 mg per 2 gummies.
Read the studies
Rhodiola and stress-related fatigue · 2009 ↗Randomised, double-blind, placebo-controlled trial; 60 adults with stress-related fatigue. Taking 576 mg of standardised SHR-5 Rhodiola extract daily for 28 days improved fatigue symptoms and selected measures of attention.
Maca, mood and perceived energy · 2016 ↗Randomised, double-blind, placebo-controlled study of 3 g daily of spray-dried red or black maca extract for 12 weeks. Researchers reported improvements in mood and perceived energy, with the strongest findings generally seen with red maca and results varying by altitude.
Pro’s Rhodiola and black maca amounts are raw-ingredient equivalents from 10:1 and 100:1 extracts respectively. The studies used SHR-5 Rhodiola and spray-dried maca extracts.
05 / Panax ginseng + Vitamins B3 & B12
Energy for the everyday
Pro combines a botanical studied during sustained mental effort with nutrients that support the body’s everyday energy processes. Vitamins B3 and B12 contribute to normal energy-yielding metabolism and the reduction of tiredness and fatigue.
Research findings & nutrient benefits
Less reported mental fatigue during sustained cognitive testing with 200 mg of a standardised Panax ginseng extract.
Better performance on a demanding subtraction task in that same placebo-controlled trial.
Support for normal energy metabolism and reduced tiredness from vitamins B3 and B12.
In Neuropic Pro: Panax ginseng equivalent to 1,000 mg, vitamin B3 16 mg and vitamin B12 1,000 µg per 2 gummies.
Read the study & nutrient evidence
Panax ginseng during sustained mental activity · 2005 ↗Double-blind, placebo-controlled crossover trial; 30 healthy young adults; 200 mg and 400 mg G115 extract. The clearest mental-fatigue and subtraction-task findings were at 200 mg.
B3 and B12: established nutrient functions ↗The GB Nutrition and Health Claims Register authorises contributions to normal energy-yielding metabolism, normal psychological function, and reduction of tiredness and fatigue.
Pro’s ginseng amount is a raw-ingredient equivalent from a 10:1 extract. The trial used the standardised G115 extract.
Plus, the supporting ingredients
Black pepper extract: included alongside the botanical blend. Its best-known compound, piperine, has been studied for its effects on the absorption of certain other substances.
Beta-alanine: an amino acid used by the body to make carnosine, a compound found naturally in muscle and other tissues.
Coconut water extract: adds a coconut-derived ingredient to Pro’s blend of botanicals, amino acids and vitamins.
More about these ingredients
Per 2 Neuropic Pro gummies: black pepper extract 5 mg, beta-alanine 25 mg and coconut water extract 150 mg.
Beta-alanine and carnosine · 2015 ↗This scientific position paper explains beta-alanine’s role in producing carnosine, which helps buffer acidity in muscle. It reviews supplementation research commonly using 4–6 g daily for at least two to four weeks.
Thoughtfully formulated for growing minds. Spark combines saffron and L-theanine with choline, essential vitamins and minerals in a stimulant-free daily gummy.
Amounts below are per 2 Neuropic Spark gummies. Ages 8–11 take 1 gummy daily, providing half these amounts. Ages 12+ take 2 daily.
01 / Saffron + L-theanine
Exploring calm and emotional balance
Saffron is one of Spark’s standout ingredients, with human research exploring mood in both teenagers and adults. L-theanine, an amino acid naturally found in tea, has separately been studied for the way people respond to stress.
What the research found
Improved self-reported emotional symptoms in teenagers taking a standardised saffron extract for eight weeks.
Improved mood in adults experiencing low mood in a larger, 12-week saffron trial.
A reduced heart-rate response to a stressful task with L-theanine in a small adult laboratory study.
Saffron and emotional wellbeing in teenagers · 2018 ↗Randomised, double-blind, placebo-controlled trial; 80 teenagers aged 12–16 with mild-to-moderate anxiety or depressive symptoms. Taking 28 mg of affron® saffron extract daily for eight weeks led to greater improvements in teenagers’ self-reported emotional symptoms than placebo.
Saffron and mood in adults · 2025 ↗Randomised, double-blind, placebo-controlled trial; 202 adults experiencing depressive symptoms. Taking 28 mg of affron® daily for 12 weeks produced greater improvements in depression scores than placebo.
L-theanine and the stress response · 2007 ↗Double-blind laboratory study involving 12 adults. L-theanine reduced the heart-rate response to a mental-arithmetic stress task compared with placebo.
Spark uses saffron standardised to 0.2% safranal. The saffron studies used a different standardised extract, affron®.
02 / L-theanine + Iodine + Zinc
The nutrients behind growing minds
ZnI
Focus starts with the brain’s everyday needs. Iodine and zinc both contribute to normal cognitive function. Alongside them, Spark includes L-theanine, which has been investigated for attention and working memory in adults.
Research findings & nutrient benefits
Normal cognitive function supported by iodine and zinc.
Faster responses on an attention task after a single dose of L-theanine in an adult trial.
More correct answers and fewer missed responses on a working-memory task in that same trial.
Per 2 Neuropic Spark gummies: 75 mg L-theanine, 75 µg iodine and 5 mg zinc.
Read the study & nutrient evidence
L-theanine, attention and working memory · 2021 ↗Randomised, double-blind, placebo-controlled trial; 50 adults aged 50–69 in the final analysis. After a single 100.6 mg dose, researchers reported faster responses on an attention task, alongside more correct answers and fewer missed responses on a working-memory task.
Iodine and zinc: established nutrient functions ↗Iodine and zinc contribute to normal cognitive function. Iodine also contributes to normal functioning of the nervous system. These functions are recognised in the GB Nutrition and Health Claims Register.
03 / Choline
Choline: essential nutrition for growing minds
Alongside saffron and L-theanine, Spark includes choline. This essential nutrient helps supply the raw materials the body uses for brain signalling and cell structure.
Why choline earns its place
A building block for acetylcholine, a chemical messenger involved in memory and other brain functions.
A component of everyday nutrition: the body makes some choline, and we also need to obtain it through food.
Per 2 Neuropic Spark gummies: 33 mg choline.
Read about choline’s role
Choline: essential nutrition and brain function ↗The NIH Office of Dietary Supplements explains how the body uses choline to make acetylcholine, a chemical messenger involved in memory, mood and nervous-system function. Choline is also needed to make important components of cell membranes.
04 / Vitamins B6 & B12
Everyday energy, without stimulants
B6B12
Spark’s B vitamins support the body’s normal energy processes. B6 and B12 both contribute to the reduction of tiredness and fatigue, normal psychological function and normal functioning of the nervous system.
What these nutrients support
Normal energy-yielding metabolism, helping the body release energy from food.
Reduction of tiredness and fatigue.
Normal psychological function and nervous-system function.
B6 and B12: everyday energy and nervous-system function ↗Vitamins B6 and B12 contribute to normal energy-yielding metabolism, the reduction of tiredness and fatigue, normal psychological function and normal functioning of the nervous system. These functions are recognised in the GB Nutrition and Health Claims Register.
Plus, our coconut-based blend
CocoVital Ingredients™ brings together coconut water, coconut extract, MCT oil and acacia fibres, with 300 mg of the blend per two Spark gummies.
It sits alongside Spark’s headline actives in a mango-flavoured, pectin-based gummy, designed to fit easily into a daily routine.
